the 10th International MDM2 Workshop

What's New

Poster awards with a maximum prize of 50,000 yen are scheduled. Please enjoy the poster session!
A tentative program is announced.
Early registration and Abstract submission have started.
Organizing committee and International organizing committee are announced.
Website released

Early Registration deadline:
July 10th, 2023

Registration re-open:
July 13th, 2023

Registration and Abstract Submission deadline:
August 21, 2023

We are looking for donations and advertisements.

Welcome Message

MDM2 and its homolog MDM4 (also known as MDMX) are the two most important negative regulators of the tumor suppressor p53 by acting as an E3 ubiquitin ligase complex to promote p53 degradation and physically binding to inhibit the p53’s transcriptional functions. These proteins are overexpressed in about 30% of human cancers. Overexpression of MDM2/MDM4 not only inhibits p53 functions but also shows p53-independent oncogenic activities. Inhibitors against MDM2 and MDM4 have been developed to reactivate wild-type p53 in tumors, some of which are currently in clinical trials.

The MDM2 Workshop has been held alternately in the U.S. and Europe every two to three years to bring together the p53/MDM2 field, present the latest research, facilitate collaboration, and exchange reagents. The 10th International MDM2 Workshop will be held in Japan, for the first time in Asia. Notably, this is the first MDM2 Workshop since the COVID-19 pandemic started. The Workshop will be held at the auditorium of the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan, on October 15-18, 2023.

The meeting will be co-organized by:

Rieko Ohki

Rieko Ohki
(NCCRI, Tokyo, Japan)

Koji Itahana

Koji Itahana
(Duke-NUS Medical School, Singapore)

Tomoo Iwakuma

Tomoo Iwakuma
(Children’s Mercy Research Institute, MO, USA)


On the first day of the workshop, we are planning a special symposium on MDM2 to discuss the historical discoveries on MDM2 and the future directions of MDM2 research.

This symposium offers a fascinating opportunity for many researchers to hear directly from the actual discoverers about the breakthroughs that are featured in textbooks such as "the biology of cancer.” Furthermore, on the third day, we will conduct special sessions aimed at bridging the rapidly advancing field of cancer immunology with the MDM2/MDM4/p53 field.

# The schedule for days 2-4 is tentative. We will finalize it after we have received all the abstracts.

The first day (Oct 15, 2023)

4:00 pm – Welcome and opening remarks
Opening Session: Celebrating the discovery and key findings of MDM2
Keynote Presentations in honor of Dr. Donna George’s retirement and her discovery of the MDM2 gene, Chair: Arnold J. Levine

4:20 – 4:50pm S1: Donna George: Keynote presentation
4:50 – 5:20pm S2: Jamil Momand & Gerry Zambetti: Keynote presentation
5:20 – 5:50pm S3: Guillermina Lozano: Keynote presentation
5:50 – 6:20pm COFFEE BREAK – Lobby
6:20 – 6:50pm S4: Lubo Vassilev & Binh Vu: Keynote presentation
6:50 – 7:20pm S5: Matthias Dobbelstein: Keynote presentation
7:30pm – Welcome party

The second day (Oct 16, 2023)

The third day (Oct 17, 2023)

The fourth day (Oct 18, 2023)



Early Registration (Before July 10th)

Academia or Non-Profit Institute Corporate
Full Conference with welcome party and
conference dinner
Faculty JPY
Trainees JPY
Corporate JPY
One-day registration (first day only) with
welcome party
Faculty JPY
Trainees JPY
Corporate JPY

Registration(Open from July 13th, Deadline August 21th)

Academia or Non-Profit Institute Corporate
Full Conference with welcome party and
conference dinner
Faculty JPY
Trainees JPY
Corporate JPY
One-day registration (first day only) with
welcome party
Faculty JPY
Trainees JPY
Corporate JPY
●Please note that onsite registration and payment will not be available

non-invited participants

Invited registration

committee members
invited speakers

Abstract submission

For registration inquiries please email Ms. Beatrice Tan at



The hotels listed below can be reserved by Yobiyose Express Travel Agency (YXP) upon request. To do so, please scroll and click on "Hotel."

  • The KEIKYU EX INN Higashiginza
  • APA Hotel Tsukiji-Eki Minami
  • Sotetsu Fresa Inn Ginza-Nanachome
  • TOKYU STAY Tsukiji
  • TOKYU STAY Ginza
  • Mitsui Garden Hotel Ginza-gochome

YXP will handle hotel bookings according to the booking request received from guests.

  • We will notify guests through email about alternative options if the requested hotel is fully booked.
  • We will send a credit card invoice via email when a room is reserved at the requested hotel (please note that the booking is not yet finalized at this stage).
  • The reservation will be canceled if the credit card payment is not processed within 72 hours following a successful booking.

Upon successful credit card payment, YXP will issue and send a Hotel Confirmation Slip to the guest.

  • The hotels listed below are located within a 10-minute walk from the workshop venue.
  • Priority is given to booking non-smoking rooms.
  • The room fee includes consumption tax (breakfast is not included).
  • Cancellations made 48 hours before check-in time are free of charge. Otherwise, a one-night room fee will be charged as a cancellation fee.

Yobiyose Express Travel Agency (YXP)
Person in charge: SASAKI Ryosuke Mr.



There are also other hotels near the venue listed below.
You can visit the hotel website and make a reservation by yourself.

Conference coordinator
Rieko Ohki
Secretariat (in English)
開催事務局 (日本語)

Restaurant information can be found in the following link:


The workshop will be held in the auditorium of the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan.

Directions to the NCCRI

Map of the NCCRI campus



National Cancer Center Research Institute (NCCRI), Tokyo, Japan


Rieko Ohki
National Cancer Center Research Institute
Koji Itahana
Duke-NUS Medical School, Singapore
Tomoo Iwakuma
Children's Mercy Research Institute, USA


Hiroyuki Mano

National Cancer Center Research Institute
Hitoshi Nakagama

National Cancer Center
Masanobu Oshima
Kanazawa University
Tomoaki Tanaka
Chiba University
Koichi Matsuda
The University of Tokyo
Koji Okamoto
Teikyo University
Hirofumi Arakawa
National Cancer Center Research Institute
Takashi Tokino
Sapporo Medical School
Manabu Kurokawa
Kent State University
Koichi Kawahara
Kagoshima University
Marco Candeias
Kyoto University
Chizu Tanikawa
The University of Tokyo



Arnold Levine
Institute for Advanced Study, US
David Lane
Karolinska Institute, Sweden
Carol Prives
Columbia University, US
Guillermina Lozano
MD Anderson Cancer Center, US
Karen Vousden
The Francis Crick Institute, UK
Wei Gu
Columbia University, US
James Manfredi
Icahn School of Medicine at Mount Sinai, US
Laura Attardi
Stanford University School of Medicine, US
Ygal Haupt
Peter MacCallum Cancer Center, Australia
Yanping Zhang
University of North Carolina at Chapel Hill, US
Hua Lu
Tulane University, US
Jiandong Chen
Moffitt Cancer Center, US
Christine Eischen
Thomas Jefferson University, US
Ute Moll
Stony Brook University, US
Matthias Dobbelstein
University Medical Center Göttingen, Germany
Pierre Hainaut
Institute for Advanced Biosciences, France



Please email us any inquiries about the conference, registration, and special accessibility needs.

Conference coordinator
Rieko Ohki
Secretariat (in English)
開催事務局 (日本語)