What's New
- 2023.06.05
- Poster awards with a maximum prize of 50,000 yen are scheduled. Please enjoy the poster session!
- 2023.05.25
- A tentative program is announced.
- 2023.04.10
- Early registration and Abstract submission have started.
- 2022.12.1
- Organizing committee and International organizing committee are announced.
- 2022.11.1
- Website released
Early Registration deadline:
July 10th, 2023
Registration re-open:
July 13th, 2023
Registration and Abstract Submission deadline:
August 21, 2023
We are looking for donations and advertisements.
Welcome Message
MDM2 and its homolog MDM4 (also known as MDMX) are the two most important negative regulators of the tumor suppressor p53 by acting as an E3 ubiquitin ligase complex to promote p53 degradation and physically binding to inhibit the p53’s transcriptional functions. These proteins are overexpressed in about 30% of human cancers. Overexpression of MDM2/MDM4 not only inhibits p53 functions but also shows p53-independent oncogenic activities. Inhibitors against MDM2 and MDM4 have been developed to reactivate wild-type p53 in tumors, some of which are currently in clinical trials.
The MDM2 Workshop has been held alternately in the U.S. and Europe every two to three years to bring together the p53/MDM2 field, present the latest research, facilitate collaboration, and exchange reagents. The 10th International MDM2 Workshop will be held in Japan, for the first time in Asia. Notably, this is the first MDM2 Workshop since the COVID-19 pandemic started. The Workshop will be held at the auditorium of the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan, on October 15-18, 2023.
The meeting will be co-organized by:
Rieko Ohki
(NCCRI, Tokyo, Japan)
Koji Itahana
(Duke-NUS Medical School, Singapore)
Tomoo Iwakuma
(Children’s Mercy Research Institute, MO, USA)
PROGRAM
On the first day of the workshop, we are planning a special symposium on MDM2 to discuss the historical discoveries on MDM2 and the future directions of MDM2 research.
This symposium offers a fascinating opportunity for many researchers to hear directly from the actual discoverers about the breakthroughs that are featured in textbooks such as "the biology of cancer.” Furthermore, on the third day, we will conduct special sessions aimed at bridging the rapidly advancing field of cancer immunology with the MDM2/MDM4/p53 field.
# The schedule for days 2-4 is tentative. We will finalize it after we have received all the abstracts.
The first day (Oct 15, 2023)
4:00 pm – Welcome and opening remarks
Opening Session: Celebrating the discovery and key findings of MDM2
Keynote Presentations in honor of Dr. Donna George’s retirement and her discovery of the MDM2 gene, Chair: Arnold J. Levine
| 4:20 – 4:50pm | S1: Donna George: Keynote presentation |
|---|---|
| 4:50 – 5:20pm | S2: Jamil Momand & Gerry Zambetti: Keynote presentation |
| 5:20 – 5:50pm | S3: Guillermina Lozano: Keynote presentation |
| 5:50 – 6:20pm | COFFEE BREAK – Lobby |
| 6:20 – 6:50pm | S4: Lubo Vassilev & Binh Vu: Keynote presentation |
| 6:50 – 7:20pm | S5: Matthias Dobbelstein: Keynote presentation |
| 7:30pm – | Welcome party |
The second day (Oct 16, 2023)
- Session 2: Novel functions of MDM2/MDM4
- Session 3: p53-independent functions of MDM2/MDM4
- Poster session-1
- Lunch break
- Session 4: Controls of p53 by MDM2/MDM4
- Session 5: Functions of p53, mutant p53, p53 family, and p53 isoforms
The third day (Oct 17, 2023)
- Session 6: MDM2/MDM4/p53 in cancer progression and beyond
- Session 7: Animal models of MDM2/MDM4/p53
- Poster session-2
- Lunch break
- Special sessions: Cancer Immunology
- Session 8: MDM2/MDM4/p53 in tumor immunity and microenvironments
- Session 9: MDM2/MDM4/p53 in cancer immunotherapy
- Workshop dinner
The fourth day (Oct 18, 2023)
- Session 10: Development of therapies targeting MDM2/MDM4/p53
- Session 11: MDM2/MDM4/p53 in human diseases
- Closing remarks
- Boxed lunch
- Optional meeting tour
SPEAKERS
REGISTRATION
Early Registration (Before July 10th)
| Academia or Non-Profit Institute | Corporate | ||
|---|---|---|---|
|
Full Conference with welcome party and conference dinner |
Faculty JPY 50,000 |
Trainees JPY 35,000 |
Corporate JPY 80,000 |
|
One-day registration (first day only) with welcome party |
Faculty JPY 15,000 |
Trainees JPY 8,000 |
Corporate JPY 20,000 |
Registration(Open from July 13th, Deadline August 21th)
| Academia or Non-Profit Institute | Corporate | ||
|---|---|---|---|
|
Full Conference with welcome party and conference dinner |
Faculty JPY 60,000 |
Trainees JPY 45,000 |
Corporate JPY 90,000 |
|
One-day registration (first day only) with welcome party |
Faculty JPY 18,000 |
Trainees JPY 10,000 |
Corporate JPY 23,000 |
For registration inquiries please email Ms. Beatrice Tan at
regn@10thmdm2.jp
参加登録手続き・カード決済「成功／失敗」などのお問合せは、
secjp@10thmdm2.jp
ACCOMMODATIONS
The hotels listed below can be reserved by Yobiyose Express Travel Agency (YXP) upon request. To do so, please scroll and click on "Hotel."
- The KEIKYU EX INN Higashiginza
- APA Hotel Tsukiji-Eki Minami
- Sotetsu Fresa Inn Ginza-Nanachome
- TOKYU STAY Tsukiji
- TOKYU STAY Ginza
- Mitsui Garden Hotel Ginza-gochome
YXP will handle hotel bookings according to the booking request received from guests.
- We will notify guests through email about alternative options if the requested hotel is fully booked.
- We will send a credit card invoice via email when a room is reserved at the requested hotel (please note that the booking is not yet finalized at this stage).
- The reservation will be canceled if the credit card payment is not processed within 72 hours following a successful booking.
Upon successful credit card payment, YXP will issue and send a Hotel Confirmation Slip to the guest.
- The hotels listed below are located within a 10-minute walk from the workshop venue.
- Priority is given to booking non-smoking rooms.
- The room fee includes consumption tax (breakfast is not included).
- Cancellations made 48 hours before check-in time are free of charge. Otherwise, a one-night room fee will be charged as a cancellation fee.
Yobiyose Express Travel Agency (YXP)
Person in charge: SASAKI Ryosuke Mr.
Click
HotelThere are also other hotels near the venue listed below.
You can visit the hotel website and make a reservation by yourself.
- HOTEL VISTA TOKYO TSUKIJI (3 min walk)
https://tokyo-tsukiji.hotel-vista.jp/en/ - VIA INN HIGASHI-GINZA (5 min walk)
https://www.viainn.com/en/higashiginza/ - Agora Tokyo Ginza (5 min walk)
https://www.agora-ginza.com/en/ - Tabist GINZA (6 min walk)
https://tabist.co.jp/en/h/N13HTBG - KOKO HOTEL Tsukiji Ginza (9 min walk)
https://koko-hotels.com/tsukiji_ginza_lang/en_t - HOTEL GRACERY GINZA (11 min walk)
https://ginza.gracery.com/#_ga=2.213773524.1586794401.1681880304-54843402.1681880304 - Ibis Styles Tokyo Ginza (11 min walk)
https://ibisstylestokyoginza.com/en
Conference coordinator
Rieko Ohki
Secretariat regn@10thmdm2.jp (in English)
開催事務局 secjp@10thmdm2.jp (日本語)
Restaurant information can be found in the following link:
https://www.google.com/maps/d/embed?mid=1VajJC3FUpXeQTNrJvCWAJTv4sKFq1no&ehbc=2E312F
VENUE
The workshop will be held in the auditorium of the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan.
Map of the NCCRI campus
ORGANIZING COMMITTEE
HOST INSTITUTION
National Cancer Center Research Institute (NCCRI), Tokyo, Japan
ORGANIZERS
- Rieko Ohki
- National Cancer Center Research Institute
- Koji Itahana
- Duke-NUS Medical School, Singapore
- Tomoo Iwakuma
- Children's Mercy Research Institute, USA
ORGANIZING COMMITTEE
- Co-organizer
Hiroyuki Mano
National Cancer Center Research Institute- Advisor
Hitoshi Nakagama
National Cancer Center- Masanobu Oshima
- Kanazawa University
- Tomoaki Tanaka
- Chiba University
- Koichi Matsuda
- The University of Tokyo
- Koji Okamoto
- Teikyo University
- Hirofumi Arakawa
- National Cancer Center Research Institute
- Takashi Tokino
- Sapporo Medical School
- Manabu Kurokawa
- Kent State University
- Koichi Kawahara
- Kagoshima University
- Marco Candeias
- Kyoto University
- Chizu Tanikawa
- The University of Tokyo
INTERNATIONAL ORGANIZING COMMITTEE
INTERNATIONAL ORGANIZING COMMITTEE
- Arnold Levine
- Institute for Advanced Study, US
- David Lane
- Karolinska Institute, Sweden
- Carol Prives
- Columbia University, US
- Guillermina Lozano
- MD Anderson Cancer Center, US
- Karen Vousden
- The Francis Crick Institute, UK
- Wei Gu
- Columbia University, US
- James Manfredi
- Icahn School of Medicine at Mount Sinai, US
- Laura Attardi
- Stanford University School of Medicine, US
- Ygal Haupt
- Peter MacCallum Cancer Center, Australia
- Yanping Zhang
- University of North Carolina at Chapel Hill, US
- Hua Lu
- Tulane University, US
- Jiandong Chen
- Moffitt Cancer Center, US
- Christine Eischen
- Thomas Jefferson University, US
- Ute Moll
- Stony Brook University, US
- Matthias Dobbelstein
- University Medical Center Göttingen, Germany
- Pierre Hainaut
- Institute for Advanced Biosciences, France
SPONSORS
CONTACT
Please email us any inquiries about the conference, registration, and special accessibility needs.
Conference coordinator
Rieko Ohki
Secretariat regn@10thmdm2.jp (in English)
開催事務局 secjp@10thmdm2.jp (日本語)
